Keytruda (Pembrolizumab): First PD-1 Inhibitor Approved for Previously Treated Unresectable or Metastatic Melanoma.
نویسنده
چکیده
منابع مشابه
Pembrolizumab
The development of the cytotoxic T-lymphocyte-associated protein 4 inhibitor ipilimumab and its approval in 2011 for the treatment of metastatic melanoma has heralded a new era in immuno-oncology. Subsequently, novel agents against the programmed death receptor 1 (PD-1)/programmed death receptor ligand 1 (PD-L1) axis have shown significant activity in melanoma and a variety of other tumor types...
متن کاملPembrolizumab: First in Class for Treatment of Metastatic Melanoma
Author's disclosures of potential conflicts of interest are found at the end of this article. M alignant melanoma accounts for only 2% of skin cancers, but it is the most deadly form of skin cancer. Melanoma rates have been increasing over the past 30 years. Melanoma is 10 to 20 times more common in Caucasians than in those of Hispanic or African descent. Metastatic (or stage IV) melanoma has a...
متن کاملCTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA4) and programmed death 1 (PD-1) immune checkpoints are negative regulators of T-cell immune function. Inhibition of these targets, resulting in increased activation of the immune system, has led to new immunotherapies for melanoma, non–small cell lung cancer, and other cancers. Ipilimumab, an inhibitor of CTLA-4, is approved for the treatmen...
متن کاملCTLA-4 and PD-1 Pathways
The cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) immune checkpoints are negative regulators of T-cell immune function. Inhibition of these targets, resulting in increased activation of the immune system, has led to new immunotherapies for melanoma, non-small cell lung cancer, and other cancers. Ipilimumab, an inhibitor of CTLA-4, is approved for the treatme...
متن کاملConsensus statement from the faculty of the Melanoma Nursing Initiative on managing adverse events
SINCE THEIR RECENT INTRODUCTION IN ONCOLOGY, programmed cell death protein 1 (PD-1) inhibitors have become a common treatment modality for unresectable or metastatic (advanced) melanoma as well as other malignancies, including non-small cell lung cancer, squamous cell carcinoma of the head and neck, Hodgkin lymphoma, renal cell carcinoma, and urothelial carcinoma (Franklin, Livingstone, Roesch,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- American health & drug benefits
دوره 8 Spec Feature شماره
صفحات -
تاریخ انتشار 2015